E. coli and the Mucosal Immune System

ESCHERICHIA COLI - MUCOSAL IMMUNE SYSTEM - ANTIBIOTIC RESISTANCE -
MICROBIOME - PROBIOTICS - NANOBODY - PHAGE THERAPY- VACCINATION

June 30 - July 2, 2024 - Ghent

Programme

Sunday June 30, 2024

Opening Session - Main Hall

Moderators: Eric Cox, Bert Devriendt

18h00

Opening Address : Introduction

Eric Cox

18h05

Keynote Lecture: Colonization factors in E. coli

Astrid Von Mentzer

18h45

Keynote Lecture: A genomics perspective of Salmonella and E. coli populations with implications to vaccine coverage.

Sandra Van Puyvelde

19h30

Welcome reception

Monday July 1, 2024

Main Hall - Ned Kahn

Moderators: Bert Devriendt & Gregers Jungersen

09h00

APN-targeting as a new oral vaccination strategy

Eric Cox

Session 1

Moderators: Bert Devriendt & Gregers Jungersen

09h30

Invited lecture: Getting a handle on E. coli’s capsular polysaccharides

Timothy Keys

10h00

1.1. Transcriptome and metabolome analyses of enterotoxigenic Escherichia coli (ETEC) during growth in LB media reveals a transient shift in gene expression during transition from logarithmic to stationary phase

Sjöling Å

10h20

Coffee-Break

10h50

1.2 Characterization of Enterotoxigenic Escherichia coli Strains in Piglets: Implications for ETEC Pathogenesis and Model Development

Verhelle A

11h10

1.3. The heat labile enterotoxin of enterotoxigenic Escherichia coli induces apoptosis in monocytes and disrupts their effector functions

Jingling M.

11h30

1.4. Development of a Recombinant Vaccine in Shigella flexneri Containing ETEC's LTB Toxin

Salvador-Erro J.

11h50

Invited Lecture: Exploring innate and adaptive immunity in experimental human ETEC infection

Kurt Hanevik

12h20

Lunch, Poster session

Main Hall - Ned Kahn

Session 2

Moderators: Moderators: Eric Cox & Kurt Havenik

13h20

Invited Lecture: Steeplechase in development of neonatal vaccine against post-weaning ETEC diarrhea

Gregers Jungersen

13h50

2.1. Aminopeptidase N-targeted Lipid Nanoparticless : A Novel Platform for Targeted Delivery of Oral mRNA Vaccines

Chen L

14h10

2.2. Development of engineered L. lactis platform combined with nanocarrier material for antigen delivery against major swine E. coli

Dell’Anno M

14h30

Invited lecture: Field evaluation of a prototype subunit vaccine to control Escherichia coli O157 in cattle

Tom McNeilly

15h00

Coffee-Break

15h30

Invited Lecture: Novel Antigen That Offers Partial Protection against Verocytotoxigenic Escherichia coli

Siobhán McClean

16h00

2.3. Characterization of Ema (Extracellular Matrix-binding Autotransporter): a novel adhesin identified in atypical enteropathogenic Escherichia coli

Hernandes R.T

16h20

Keynote Lecture: License to Clump

Alyson Hockenberry

17h00

End of scientific Program

18h00

Congress Dinner in St Peter's Abbey

Tuesday July 2, 2024

Main Hall - Ned Kahn

Moderators: Jan Paeshuyse & Johan Dicksved

09h00

Keynote Lecture: The Shigella flexneri “invasome” revealed by human intestinal epithelial organoid infections

Maria Letizia Di Martino

09h40

Invited lecture: Host-pathogen interaction: Modulation of E. coli by the Host

Bert Devriendt

Session 3

Moderators: Jan Paeshuyse & Johan Dicksved

10h10

3.1. The AcrAB efflux pump impacts the invasion of epithelial cells by Shigella flexneri

Collucia M

10h30

Coffee-Break

11h00

3.2. Antibiotics that do not cause Shiga-toxin mediated disease in C. rodentium φstx2d-infected mice and their effect on the intestinal microbiota

Mühlen S

11h20

3.3. External factors influence intrinsic differences in Stx2e secretion by porcine Shiga toxin-producing Escherichia coli strains

Van Hoorde S.

11h40

3.4. . Influence of metallic ions on the profile to antimicrobials and on the formation of biofilms in strains of Uropathogenic Escherichia coli (UPEC), Escherichia coli Enteroaggregative (EAEC) and Escherichia coli K-12

Campos C. A

12h00

Invited lecture: Lactoferrin: antimicrobial and immunomodulating

Matthias Dierick

12h30

Lunch, Poster session

Session 4

Moderators: Sven Arnouts & Matthias Dierick

13h30

Invited lecture: Phage therapy in poultry

Catharine Schouler

14h00

4.1. Coverage of EXPEC4V and EXPEC9V vaccine candidates of globally collected Escherichia coli from adults hospitalized with invasive E. coli disease

Arconada Nuin E.

14h20

4.2. Genotypic and phenotypic traits of a hybrid ExPEC/EAEC strain isolated from human bacteremia

Elias W.P.

11h20

4.3. The colibactin-producing Escherichia coli alters the tumor microenvironment to immunosuppressive lipid overload facilitating colorectal cancer progression and chemoresistance

de Oliviera Alves N

15h10

Coffee-Break

15h40

4.5. Colibactin-induced genotoxicity and colorectal cancer exacerbation critically depend on adhesin-mediated epithelial binding

Jans M.

16h00

Invited Lecture: Plant-derived extracellular vesicles for oral mRNA vaccine delivery

Lucia Massari

16h30

Keynote Lecture: Oral adjuvants

Ed Lavelle

17h00

End of scientific Program

18h30

Guided tour in the Historic center of Ghent followed by Belgian Beer tasting